In Belize, which is exposed to a high level of risk from meteorological hazards, the World Bank worked with the Government to carry out an assessment and prioritization process that resulted in identification of investments aimed at increasing the country’s resilience to the impacts of natural hazards by improving key road segments in the road network. The prioritization process and lessons learned from it are presented and discussed in this Practitioners’ Guide, which aims to provide guidance for the prioritization of climate- resilient investments in road infrastructure by presenting a general methodology, a conceptual framework, and a case study of the process that was conducted in Belize.